The Anu living in their home system in the belt of Orion have been aware of the situation on Earth for a long time. They did not know exactly what happened initially, but they did realise that their crew had gone mad, and had started to interfere inexcusably with the natives.
With every crew they sent after it either going mad as well or being destroyed, they have largely ignored Earth after constraining their people from leaving.
It is likely that eventually, when humanity grows up and heals from its childhood abuse, we will connect with the Anu and help them understand what went wrong in their own development, and show them how to work through their buried primitive heritage.